Animal Studies


Congenital polydactyly deformities in maternal exposure to Chinese medicines were commonly found. All the exposure were during the organogenesis period E8–E15 in mice. Unilateral or bilateral polydactyly appendage was found when exposed to 12 Chinese medicines (open arrows) at E15. Vehicle control with normal digit (closed arrow) at E15 is shown on the top right of this picture. Safranin O cartilage staining showed the presence of cartilage (red stains) and mucin (blue stains) in the polydactyly appendage (open arrow) in the study group, but not in the normal digits (closed arrow) in the control group. References: Wang CC, Li L, Tang LY, Leung PC. 2012. Safety evaluation of commonly used Chinese herbal medicines during pregnancy in mice. Hum Reprod 27, 2448-2456.