Clinical Studies

Quality of Trials - Infertility

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Most of the clinical trials of infertility have a low risk of bias due to adequate sequence generation; the methods of dividing participants into different groups were clearly described. Although some trials noted the methods for blinding, many had unclear descriptions of blinding and allocation concealment. Among these studies, the one with the lowest risk of bias was performed by Wu (Wu, et al. 2006). In that study, although the risk of selective reporting is unknown, all other biases were clearly described and of low risk. References: Ren X. 2002. Effectiveness comparesion of two stimulate ovulation treatment on non-sensitive to conventional therapy of polycystic ovary syndrome. J. Pract. Obstet. Gynecol. 18: 351-352. Hua L, Wu Y, Zhang J, Cai S, Huang Y, Tong Q, Zhang Q. 2003. Clinical Study of Yishen Jianpi Yangxue Tongli Therapy in Treating Polycystic Ovary Syndrome. Chin. J. Integr. Tradit. West. Med. 23: 819-822. Liao Y. 2004. 80 cases clinical observation of YU GONG WAN and Clomifene for unovulation infertility J. Chin. Integr. Tradit. West. Med. 2. Shao R, Lang F, Cai J, Yan L. 2004. Clinical Observation on Treatment of Stein-Leventhal Syndrome Caused Sterility by Combined Use of Clomiphene and Chinese Nourishing Shen and Activating Blood Circulation Drugs. Chin. J. Integr. Tradit. West. Med. 24: 41-43. Xia Y, Cai L, Zhang S, Yue K, Wang S, Yao L, ZHang X. 2004. Therapeutic Effect of Chinese Herbal Medicines for Nourishing Blood and Reinforcing Shen in Treating Patients with Anovulatory Sterility of Shen-deficiency Type and Its Influence on the Hemodynamics in Ovarian and Uterine Arteries. Chin. J. Integr. Tradit. West. Med. 24: 299-301. Zhang J, Wang X. 2004. 30 cases of BU SHEN YANG XUE FANG and Clomifene for unovulation infertility JTCM. Apr. 45: 280-281. Ge X, Ying Z. 2006. 60 cases of combining traditional Chinese and western medicine treatment for ovulation disorder infertility Pract. Chin. J. Integr. Trad. West. Med. 6:29-30. Li X, Li L, Fu F, Hu X. 2007. Clinical Research on Lingzhu Infusion and Shenqi Capsule Sequential Therapy for Polycystic Ovarian Syndrome. J. Tradit. Chin. Med. 48: 1079-1081. Ye D, Xu L, Lu R. 2007. Clinical Observation on Laparoscopic Ovarian Electrocauterization Combined with Cycle Treatment of Traditional Chinese Medicine for Type Phlegm-damp Refractory Polycystic Ovary Syndrome. J. Guangzhou Uni. Tradit. Chin. Med. 24: 445-448. Liang R, Liu J, Lu J, Zhang H. 2008. Treatment of Refractory Polycystic Ovary Syndrome by Bushen Huoxue Method Combined with Ultrasound-guided Follicle Aspiration. Chin J. Integr Tradit West Med 28:314-317. Ma H, Lai M, Liu H, Song C, Pan S. 2009. Clinical observation of integrated therapy of Chinese and Western Medicine on 85 patients with infertility caused by PCOS. J. Tradit. Chin. Med. Univ. Hunan 29: 47-48. Wu S, Chen X, Chen W, Su S. 2006. Clinical trials for combination of Laparoscope and NEIYI pills or NEIYI colon hydrotherapy one endometriosis. J. Liaoning Uni. Tradit. Chin. Med. 8: 5-6.